From 1 December 2017, the use of Common Repository for Referral submissions replaces the use of CESP and CD/DVD for sending the Referral submissions to the National Competent Authorities (NCAs). All human referral submissions sent to the EMA will be considered delivered to all NCAs representatives and alternates. Submissions for all referrals should only be made using the EMA eSubmission Gateway/Web Client. Additional copies should not be submitted directly to the NCAs on CD/DVD or via CESP as this might lead to validation issues and cause delays.