ICH Q3C(R6) Revised PDE for Methyl isobutyl ketone and New PDE for Triethylamine

The ICH Expert Working Group (EWG) responsible for the maintenance of the Q3C Guideline has revised the Permitted Daily Exposure (PDE) for Methyl isobutyl ketone (MIBK) which was listed in ICH Q3C(R5) as a Class 3 solvent (“solvents with low toxic potential”).