An updated version of the PLM Portal (eAF) guide to registration is now available on PLM Portal eAF (DADI). The guide aims to support the users of the eAF Portal in completing the registration steps before accessing the PLM Portal. Most of these steps are independent from the PLM Portal eAF and correspond to those to obtain registration to use other European Medicines Agency (EMA) systems. Applicants are invited to register for the new PLM Portal with the support of this updated guide.